ANBI receives fresh frozen plasma for fractionation from the blood transfusion services. These units are tested for several viral markers, before they are combined to form a plasma pool.

B Various manufacturing processes are applied to extract different proteins. These are formulated into sterile products. NBI utilises a process of cold ethanol fractionation to separate plasma of human origin into intermediate protein fractions. The various fractions undergo purification by precipitation, centrifugation and filtration. Formulations and sterile filling processes are employed to produce sterile final products.

CAfter extensive Quality Control testing, products are released and distributed to pharmacies throughout South Africa.